Product ID:2'-DEOXYCYTIDINE FREE BASE, D0883
MSDS Date:07/01/1999
FSC:6505
NIIN:00N092752
Status Code:A
MSDS Number: CJTPK

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

2'-DEOXYCYTIDINE FREE BASE

CAS: 951-77-9

RTECS: HA3800000

Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: MAY BE HARMFUL BY
INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION.
MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS
MEMBRANES AND UPPER RESPIRATORY TRA CT. THE TOXICOLOGICAL
PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ADDITIONAL
INFORMATION: DEOXYCYTIDINE HAS BEEN FOUND TO BE MARKEDLY LESS TOXIC
THAN ITS DIDEOXY COUNTERPART, DIDEOXYCYTIDINE. WH EN USED IN
CONJUNCTION WITH SOME ANTI-VIRAL CHEMICAL THERAPIES, DEOXYCYTIDINE
HAS BEEN FOUND TO DIMINISH SOME OF THE TOXIC SIDE EFFECTS
ASSOCIATED WITH CHEMOTHERAPY. ALSO, SEE TOXICOLOGICAL INFORMATIO N.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IN CASE OF CONTACT,
IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS AMOUNTS OF WATER.
INHALATI ON: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON
IS CONSCIO US. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
REUSE.

Extinguishing Media:NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE
TO SURROUNDING FIRE CONDITIONS.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT TO PREVENT CONTACT WITH SKIN AND EYES.
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:IMPERVIOUS PROTECTIVE CLOTHING. SWEEP UP,
PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS
COMPLETE.

Handling and Storage Precautions:KEEP TIGHTLY CLOSED. STORE IN A COOL,
DRY PLACE.
Other Precautions:AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN AND
CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. WASH THOROUGHLY
AFTER HANDLING.

Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:COMPATIBLE CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
Supplemental Safety and Health

Solubility in Water:SOLUBLE
Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
CARBON DIOXIDE, NITROGEN OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS #: HA3800000 CYTIDINE, 2'-DEOXY-.
TARGET ORGAN DATA: EFFECTS ON FERTILITY (POST-IMPLANTATION
MORTALITY). ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL
SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN
RTECS FOR COMPLETE INFORMATION.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:REVIEWS, STANDARDS AND REGULATIONS:
OEL=MAK. EPA GENETOX PROGRAM 1988, NEGATIVE: V79 CELL CULTURE-GENE
MUTATION. EPA GENETOX PROGRAM 1988, INCONCLUSIVE: IN VITRO
SCE-HUMAN LYMPHOCYTES; IN VITRO SCE-HU MAN. EPA TSCA SECTION 8(B)
CHEMICAL INVENTORY.